Olympiacos 0-3 Atalanta*
Gol: 0-1 Joakim Maehle (40), 0-2 Ruslan Malinovsky (67), 0-3 Ruslan Malinovsky (69)
Real Sociedad 1-3 RB Leipzig*
Gol: 0-1 Willi Orban (39), 0-2 Andre Silva (59), 1-2 Martin Zubimendi (67), 1-3 Emil Forsberg (89)
Real Betis* 0-0 Zenit St. Petersburg
Braga* 2-0 Sheriff Tiraspol (Braga menang adu penalti)
Gol: 1-0 Iuri Medeiros (17), 2-0 Ricardo Horta (43)
Napoli 2-4 Barcelona*
Gol: 0-1 Jordi Alba (8), 0-2 Frenkie de Jong (13), 1-2 Lorenzo Insigne (23), 1-3 Gerard Pique (45), 1-4 P. Aubameyang (59), 2-4 Matteo Politano (87)
Rangers* 2-2 Dortmund